GESTATIONAL TROPHOBLASTIC DISEASE

Gestational trophoblastic disease (GTD) is a group of tumors defined by abnormal proliferation. GTD divided into hydatidiform moles (contain villi) and other neoplasms (lack villi).1 The malignant forms the are also collectively known as gestational or neoplasia (GTN).GTN includes invasive mole, choriocarcinoma, placental site tumor, epithelioid tumor. Southeast Asia Japan have highest reported incidence estimated to be two in 1000 pregnancies. In high-income countries, complete mole approximately 1–3 per pregnancies, partial about 3 Approximately 15–20% patients will treated for after evacuation mole. develop from proliferation tissue form botryoid arranged vesicles. Risk factors include extremes age, ethnicity, prior history an HM, suggesting genetic basis its etiology. causes broad spectrum different symptoms. most frequent clinical symptom vaginal bleeding. Other signs uterine enlargement more significant than expected absent fetal heart tones, cystic ovary enlargement, hyperemesis gravidarum, abnormally high level β-hCG age. Ultrasound gold standard non-invasive techniques, but histological examination necessary reach final diagnosis. Different treatment modalities available neoplasm depending on type stage; these D&C (dilation curettage), chemotherapy, hysterectomy, combination these.2 prognostic score GTN FIGO 0–6 low-risk 7 high-risk group. All who should up surveillance monitoring. Most relapses occur within first year completion chemotherapy. A generally approved schedule indicates monitoring weekly six weeks chemotherapy followed biweekly measurements until months Afterward, biannual measurement five years sufficient.1 Seeing this, determination diagnosis becomes very important. With proper diagnosis, management patient improve.